Release date: 2018-06-19
Science · Signal
June 12, 2018
The sinus node is the endogenous pacemaker of the heart. Scientists at the National Institute of Aging, a cardiovascular laboratory, used the isolated human sinus node cells to discover the molecular mechanisms that trigger the rhythmic contraction of the heart. Studies have shown that the periodic oscillations of calcium ions and membrane potential form two interdependent "clocks" that collectively spontaneously generate electrical signals. In addition, downstream signaling of the beta-adrenergic receptor enhances the coupling between these two clocks and may induce electrical activity in some cells that are not beating. Sinus arrest is a disease caused by sinus node dysfunction and is currently treated with a permanent implanted pacemaker. The study of the mechanism of pacing activity in human sinus node cells may help develop better treatments for sinus arrest.
Source: Technology Daily
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