Three transgenic ewes aged over one year will form China’s first “animal drug factory†and will continue to “produce†vaccines. The reporter learned on the 18th that the animal mammary gland bioreactor base of China Agricultural University has developed four drugs with drugs. The transgenic sheep of the gene, three of which are pregnant, will begin to produce milk after laying their lambs from March to April of this year. Once the test is passed, scientists will produce vaccines from the genetically modified sheep's milk. According to Professor Chen Yongfu, the person in charge of the project and the China Agricultural University, the team took out the protein gene of the virus envelope and added the biological original that guides the synthesis of the virus protein in the mammary gland. Through microinjection, the treated gene was injected into the sheep. In the fertilized egg, after a period of incubation, the embryo was transplanted into the native Little Tail Han sheep for development. Five months later, a genetically modified sheep with a viral vaccine gene was born. The four genetically modified sheep are all genetically modified for the Bursal Disease virus vaccine. Bursal disease is an animal infectious disease that specifically destroys the chicken's immune system. It is known as chicken AIDS, and the period of clinical trials for veterinary drugs is higher than humans. The use of drugs is much shorter, so the research team begins with veterinary drugs and will also conduct tests on human drugs. “These four sheep can be counted as one hundred.†Professor Chen said that the first batch of embryos transplanted a total of 100 genetically modified sheep, of which there are three to forty pregnant, produced the lambs through molecular testing, only one is carrying a vaccine The genetically modified sheep of the gene, the second batch of 100 transgenic sheep embryos, and finally three transgenic sheep, have a success rate of between 1% and 5%. The reporter saw at the base that these four baby goats were alive and in good health. Professor Chen said that three of the ewes were pregnant. In March of this year, the production and normal milk production will be completed no later than April. The theory shows that the genetically modified sheep produced according to this method will produce goat milk with a viral vaccine. The vaccine can be obtained through extraction. In general, most people use E. coli or eukaryotic cell culture broth to cultivate vaccines. The production of animal mammary gland vaccines not only has a much higher output than traditional methods, but also has a good vaccine activity. Based on this, various countries have now developed “animal drug factories†and are preparing to industrialize them. The low drug content in genetically modified goat milk has been a bottleneck for domestic and international access to genetically modified goat milk. If the vaccine contained in each liter of genetically modified goat's milk contains at least one gram, it proves that the genetically modified sheep has been successfully tested and industrialized. Application prospects. In this regard, Professor Chen, who had cultivated China's first cloned cow, was full of confidence. He said that the research team had used hormone-urging methods to allow the GM sheep to produce milk in advance. As a result, a genetically modified sheep exceeded the target at that time. Every liter of goat milk contains 2 grams of vaccine, "the normal output of goat's milk should be much thicker than the hormone-driven goat milk, and the problem is not big." Professor Chen said. Professor Chen told reporters that if the GM sheep test is successful, it will directly transfer genes that have been stably expressed to cattle, and then cultivate genetically modified cattle to produce a gram vaccine per kilogram of milk for a cow that produces 5,000 kilograms of milk per year. Two cows will produce 10 kilograms of vaccine a year, while a chicken will only need 10 micrograms to make a single shot. Two cows will have enough vaccine for 1 billion chickens. The industrial application prospects are very promising.
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