According to the JACC study, patients with atrial fibrillation have a high risk of death with a digoxin concentration of more than 1.2 ng/ml.
March 7, 2018 Source: China Circulation Author: xujing
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The JACC published study showed that the risk of death in patients with atrial fibrillation taking digoxin was independently associated with digoxin plasma concentrations, with or without heart failure. The risk of death is highest when the digoxin blood concentration exceeds 1.2 ng/ml.
Patients with serum digoxin concentrations ≥1.2 ng/ml had a 56% increased risk of death compared with those who did not receive digoxin.
Further analysis showed that for every 0.5 ng/ml increase in serum digoxin concentration, the risk of death increased by 19%.
In addition, the researchers also found that patients with new digoxin increased the risk of death by 78% and the risk of sudden cardiac death by 1.3 times.
The study included 17 897 patients, and 5824 (32.5%) patients received digoxin treatment at baseline. The use of baseline digoxin is not associated with an increased risk of death.
Source: Lopes RD, et al. Digoxin and Mortality in Patients With Atrial Fibrillation. JACC 2018, 71(10): DOI:10.1016/j.jacc.2017.12.060.
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