According to the British "Nature·Communication" magazine published a new medical breakthrough on the 30th: Duke-National University of Singapore medical school successfully developed a new method of artificial cultivation of human cells, which can generate the tissue needed for skin transplantation, is expected to be applied to treatment Severe burns in the body and other skin problems.
Self-transplantation is a common method for treating skin defects caused by trauma, burns and other factors. In recent years, skin grafting has made great progress, and the medical profession has been able to repair up to 90% of the epidermis of patients with severe skin wounds or burns. This type of treatment requires first collecting skin cells from the patient, culturing the cells into a large piece of tissue in vitro, and then transplanting them onto the wound surface.
It is often necessary to add mouse cells in the cell culture medium to support tissue growth. But this mixture of human/mouse cells exposes patients to the risk of large-scale infections and adverse immune responses.
Duke, a researcher at the National University of Singapore School of Medicine, Dr. Trego Wassen and colleagues found that two specific variants of laminin commonly found in humans support skin cell growth in a similar manner. Laminin is a non-collagen sugar, also known as lamellar, which constitutes the interstitial space. Its biological function is the medium in which cells adhere to the matrix and binds to various basement membrane components to regulate cell growth and differentiation. The results of this study have enabled researchers to successfully establish animal-free human cell culture systems for skin transplantation without using mouse cells.
It has been confirmed that the skin tissue obtained by this method has been successfully transplanted into mice. This will provide hope for recovery for patients with skin injuries caused by trauma, burns and other factors.
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