The Moscow Academy of Medical Sciences and three other institutes jointly developed a method of using genetically modified potatoes to develop anti-hepatitis B vaccines. Relevant experts pointed out that the results of this study are of great significance to the use of plants for the development of antiviral vaccines. Transgenic potatoes may become a promising plant for the development of antiviral vaccines. Antigen is a foreign protein that enters the body and produces antibodies. The initial stage of any vaccine action is such a process. The problem of the source of the antigen arises in the development of any vaccine. In most cases, antigenic proteins are obtained by genetic engineering methods. That is, virus gene proteins are implanted into microorganisms or plants for cultivation. In recent years, researchers have used transgenic plants to develop antiviral vaccines. This method is both economical and safer than the traditional way of using bacteria to develop antiviral vaccines because plants are virus free. Russian researchers used the two protein genetic engineering factors containing hepatitis B virus HBsAg to develop anti-hepatitis B virus vaccines. First, the potato leaves were infected with the above two genetic engineering factors, and then the transgenic potatoes were grown using the leaves. One of the protein genetic engineering factors only ensures the synthesis of antigens in potato tubers, and the other protein genetic engineering factor not only synthesizes antigens in potato tubers, but also in leaves and the like. Finally, the antigenic material was isolated from potatoes by gel filtration. After analyzing the obtained antigenic proteins, researchers found that the antigens that were grown using genetically modified potatoes could be combined into oligomers. Compared with other molecules, the oligomers have strong immunity and antigen activity, and they are also stable. Its antigenic activity can be maintained in plant extracts for 7 days at a temperature of 4 degrees Celsius. Researchers are expected to develop an anti-hepatitis B vaccine based on this antigen.
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