Researchers at the University of Dundee have found that mouse skin cancer is similar to human skin cancer and provides a model for developing new drugs and finding new ways to prevent disease.
Skin cancer is the most common cancer in the world and is on the rise. During the 10-year period from 2001 to 2011, the incidence of disease in Scotland increased by more than 50%, and about 3,000 new cases are diagnosed each year.
In many cases, skin cancer can be removed, but they are still the leading cause of morbidity and mortality, especially in certain high-risk groups such as organ transplant recipients and inflammatory bowel disease patients.
To date, no effective preclinical models have been available for testing and developing new treatments and providing detailed studies of skin cancer development. Now the Dundee team says they found that mice can provide new insights into non-melanoma skin cancer.
Albena Dinkova-Kostova, professor of chemical biology at the University School of Medicine, said: "There is an urgent need to find an effective preventive and therapeutic approach, but there is no suitable preclinical model."
"We have developed a new preclinical model of UVR-induced skin cancer. Detailed analysis of tumor histopathology and deep sequencing of genomic DNA isolated from tumor tissue reveals that mouse skin tumors accurately represent humans.
“We recommend using this model to further study the development of skin cancer and to test the preventive and therapeutic efficacy of potential agents.â€
“Special needs to develop new treatments to help high-risk groups such as transplant patients.â€
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