Release date: 2017-06-20
Researchers at the Boston University Biodesign Center have developed a technique for injecting cell-filled patches into 3D prints that can be used to grow healthy blood vessels. This 3D printing technique may be used for ischemic therapy. The study was conducted under the direction of Professor Christopher Chen, Director of the Center, with participants from Stanford University.
Ischemia means that your heart muscle does not get enough oxygen, which is usually caused by narrowing or occlusion of the arteries. For most people, this is a temporary situation, but the consequences can sometimes be severe: ischemia can occasionally lead to a heart attack, stroke, gangrene or other serious condition. 
"Therapeutic angiogenesis, when growth factors are injected to encourage the growth of new blood vessels, is a promising experimental method for treating ischemia. But in practice, the new branch of germination forms an unorganized and distorted network. It looks like a hair ball, blood can't flow effectively. We want to see if we can solve this problem by organizing them," Professor Chen said.
Finally, the research team designed two printable 3D patches, one of which was pre-organized into a specific structure and the other was simply injected into the cell without any organizational structure. Using high-end technology from Boston biomedical technology company Chenolign and with the help of the company's 3D printing experts, the research team was able to quickly iterate through new designs with fine print details up to 100 microns. 
Professor Christopher Chen
Tests have shown that patches with pre-organized structures outperform "hairballs" in reducing ischemic prevalence. "Pre-organized structures on the patch help guide the formation of new blood vessels, which seem to transport enough blood for downstream tissues. Although not fully recovered, we observed a functional recovery of function in ischemic tissue," Chen The professor explained.
This preclinical work demonstrates a novel approach to direct blood flow to specific areas of the body. Enhanced blood nutrition provides valuable oxygen to heal and functionally preserve vital organs such as the heart and limbs.
In the future, the research team will continue to study the scalability of this 3D printing patch and will experiment with different structures to see if there is a more efficient structure.
Source: Tiangongshe
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