novel! Scientists develop 3D devices to quantify tumor cells in the blood

Release date: 2017-07-21



New equipment at work: The fiber emits blue light, illuminating cell samples flowing from left to right. (Source: URV)

On July 16th, the Nature publication "Scientific Reports" published an article entitled "Optofluidic device for the quantification of circulating tumor cells in breast cancer", which revealed a quantitative microscopic examination of circulating tumor cells in the blood of breast cancer patients. Flow control equipment.

This new portable device was developed by a research team from the School of Physics and Inorganic Chemistry at the University of Rovira, Virginia (URV). It can measure the number of tumor cells in blood samples in real time, and has the advantages of high efficiency, convenience and non-invasiveness, which can improve the efficiency of cancer monitoring, diagnosis and treatment.

Circulating tumor cells

Circulating Tumor Cells (CTCs) are tumor cells that are detached from tumor lesions and spread to the blood. They are an important cause of postoperative recurrence and metastasis in patients with malignant tumors.

As an important marker for tumor detection, liquid biopsy based on CTCs is one of the most important methods for non-invasive diagnosis and real-time therapeutic monitoring of cancer. It can realize early screening, efficacy monitoring, recurrence and metastasis detection, prognosis evaluation and drug resistance detection. And guide individualized treatment.



Research team (Source: URV)

3D microfluidic device

The microfluidic device developed by the URV team is capable of quantitatively circulating tumor cells, including two microsystems: a microfluidic system and an optical system.



New device detects tumor cells in the blood (Source: URV)

Among them, the microfluidic system is used to control the blood cell flow rate, and the optical system uses two optical fibers (laser diodes and photodetectors) to analyze and count cancer cells and non-cancer cells. The ratio of the two types of cells can reflect the occurrence and development of cancer.

The system is capable of detecting breast cancer patients at all stages and can detect other tumors by analyzing different antibodies in the blood sample.

Source: Bio-Exploration

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The purpose of this training program is not a detailed physical justification of the principles of the «8D-LRIS» device, since different devices are designed differently. Currently, there are several manufacturers of this equipment, [spinoffs" from the original research group. In particular, in the original version of Russian, the headphones were used as magneto-inductors with an oscillation frequency, which is close to the thetarhythm of the brain, while in later versions of the device - as a conductor of electromagnetic waves that are close to the alpha rhythm of the brain. A good effect is obtained from the use of electromagnetic waves as a trigger mechanism for the study of a healthy body.Also, in many other versions of the device, laser emitters are used to affect the brain of the patient.Using the laser leads to an increase of the resonant response. However, there is a risk of adverse effects of such exposure, so the laser
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Assessment of the chakras and aura.

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