New strategies for prevention and treatment of Alzheimer's disease
December 11, 2018 Source: Health News Network Author: Li Zhe
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, Guo Dongsheng, a research group of Nankai University, and Professor Bart Jan Lavo, of the University of Münster in Germany, have made breakthroughs in co-assembling heteropolyvalent identification for inhibiting protein fibrosis, and are nerves such as Alzheimer's disease. The prevention and treatment of sexual diseases provides a new supramolecular strategy. Related papers were published in the journal Nature and Chemistry.
Alzheimer's disease and Parkinson's disease are all neurodegenerative diseases, which bring pain and burden to patients, families and society, and urgently need effective drugs.
"The misfolding of proteins to form amyloid fibrosis is the leading cause of various neurological diseases such as Alzheimer's, Parkinson's, Type 2 diabetes and Huntington's disease." Guo Dongsheng said that inhibition of protein fibrosis is the treatment of these diseases. One of the main programs, its core foundation is molecular recognition. Considering the improvement of therapeutic effect and reducing toxic and side effects, designing synthetic receptors to achieve selective and strong bonding of target proteins is a key scientific problem to be solved in this field. As a typical biological macromolecule, protein has the characteristics of multiple sites and site diversity. Therefore, compared with monovalent recognition and multivalent recognition, heteropolyvalent recognition has significant advantages, which can effectively enhance the intensity of interaction with proteins. Specificity. This study is not only time consuming, but also expensive to synthesize and separate purification, and requires precise control of the spatial arrangement of the site of action.
Guo Dongsheng's research group started from the third generation of supramolecular host calixarene, based on molecular design and synthesis, and carried out research based on molecular recognition and assembly physicochemical properties. "The Bart Young Lavo team has long been committed to the study of the second generation of supramolecular host cyclodextrins. We have made these two molecules 'married' to form a family, ie, both parents cyclodextrin and calixene "Assembly." Guo Dongsheng said, "The heteropolyvalent recognition platform was constructed by the co-assembly of amphiphilic cyclodextrin and calixarene." The co-assembly has nanomolar bonding ability for Alzheimer's disease-related proteins. And exhibits good selectivity, not only inhibits Alzheimer's disease-associated protein fibrosis, but also dissolves fibrotic amyloid. Cell experiments have shown that the co-assembly is biocompatible and can significantly reduce the cytotoxicity of amyloid. In addition, the concept of co-assembly heteropolyvalence recognition can be extended to inhibit misfolding of other proteins, and has broad application prospects.
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