Angiogenesis refers to the differentiation of endothelial cells from an existing vascular network to form new blood vessels. Angiogenesis involves the following processes: migration and proliferation of vascular endothelial cells, degradation of vascular basement membranes, expression of proteolytic enzymes and degradation of extracellular matrices, rearrangement of newly formed extracellular matrices, and formation of endothelial cell vascular walls. The process of angiogenesis involves, under appropriate conditions, endothelial cells can form microvascular or small tubular structures by self-assembly. Anti-angiogenesis has become one of the important strategies for the treatment of diseases such as tumor metastasis, diabetic retinopathy, and rheumatoid arthritis.
As a global leader in cell behavioral analysis, Trevigen offers complete angiogenesis experimental solutions. Among them, the in vitro angiogenesis assay kit and the in vitro angiogenesis endothelial cell infiltration assay reagent are used to evaluate the angiogenic factors at the cellular level, the former can be used to detect endothelial cell tube formation inducers and inhibitors, the latter Accelerate screening of compounds that affect the passage of this vascular endothelial cell through the basement membrane. In addition, Trevigen's patented DIVAA product is the world's first detection system for quantitative detection of angiogenesis in vivo.
Directed In Vivo Angiogenesis Assay (DIVAA) is the world's first detection system for quantitative detection of angiogenesis in vivo, and the experiment is reproducible. A portable silicone column (vascular reactor, angioreactors, with or without angiogenic regulatory factors) containing 20 μl of Trevigen's basement membrane extract (BME) was implanted subcutaneously in nude mice. Nine days after transplantation, vascular endothelial cells grow into BME and generate blood vessels. Researchers can add different angiogenic regulatory factors (promoting or inhibiting angiogenic factors such as FGF-2, VEGF, MMP2, adrenomedullin, TIMP-2, and CD97) to BME to observe their effects on angiogenesis in vivo. Impact. DIVAA provides a standardized test protocol for the regenerative and quantifiable analysis of angiogenesis in vivo. The vascular reactor avoids errors due to absorption values ​​of the mouse basement membrane extract. In addition, the vascular reactor requires only a small amount of material, saving the use of BME and test compounds, and up to four reactors can be implanted in each mouse, which increases statistical significance. DIVAA has been used in a variety of applications.
Trevigen's patented DIVAA series of assay kits are designed for the assessment of angiogenesis inhibition/activation. The kit contains 48 vascular reactors (a silicone column that can be implanted in the body) and Trevigen's patented BME matrix (with very low cytotoxicity, verified by rigorous bacteria/fungus/mycoplasma, etc.) The toxin content is extremely low, and the necessary growth factors and other reagents required for angiogenesis can be analyzed 48 times. A unique Angiorack stent design is also included in the initial kit to facilitate the positioning of the vascular reactor during initial installation.
| Product name | Brand | Item number | product manual |
| Cultrex® DVAA Inhibition Kit | Trevigen | 3450-048-IK | 48 fluorescence analysis |
| Cultrex® DIVAA Activation Kit | Trevigen | 3450-048-K | 48 fluorescence analysis |
| Cultrex® DIVAA Starter Kit | Trevigen | 3450-048-SK | 48 fluorescence analysis |
| Cultrex® DIVAA FITC-Lectin & Buffer | Trevigen | 3450-048-FL | 48 fluorescence analysis |
| Cultrex® DIVAA Angioreactor and BME | Trevigen | 3450-048-DA | 48 fluorescence analysis |
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