Release date: 2015-05-08
Recently, scientists from the United States published an article online on the journal of clinical cancer research on the discovery of potential drug targets for melanoma.
In the study, researchers found a specific enzyme expressed in high water skin in a clinical sample of melanoma, which they believe is an important factor in promoting melanoma growth. This enzyme called ITK (interleukin-2 inducible T-cell kinase) has never been found to have any effect in the growth of solid tumors in previous studies. Under normal circumstances, ITK is mainly expressed in a subset of immune cells. .
The researchers pointed out that ITK is highly expressed in melanoma cells, and reducing ITK activity can inhibit melanoma cell growth. Therefore, ITK may be a potential drug target for the treatment of melanoma. But so far, only one drug that inhibits ITK has been approved for use in the treatment of hematological cancer. Therefore, the development of therapeutic drugs targeting ITK is of great significance for the treatment of melanoma.
In the study, the researchers analyzed normal skin tissue, non-cancerous skin imperfections, and melanoma samples and found that ITK is expressed more highly in in situ melanoma and metastatic melanoma, and in metastatic melanoma. In the sample, 91% of tumor samples had higher levels of ITK expression than non-cancerous skin imperfections. When the expression of ITK is inhibited in melanoma cells, cell proliferation is slowed down and migration is weakened, and inhibition of ITK enzyme activity by an inhibitor can also attenuate cell proliferation and migration ability.
Previous studies have shown that ITK is mainly expressed in specific immune cell subpopulations, and this study found that ITK has high expression in melanoma cells and plays an important role in promoting melanoma cell growth, so the development of inhibitors targeting ITK drugs or It is important to inhibit the growth of melanoma and achieve therapeutic effects.
Source: Bio Valley
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