[China Pharmaceutical Network Technology Development] Recently, researchers at Hefei University of Technology have prepared a series of multi-functional "integration and treatment integration" polymer nano drug carriers, and early warning and intervention of cancer may become possible. The research results have been published in the internationally renowned journals Diagnostic Therapeutics and Macromolecules.
According to reports, to ensure that drug molecules can successfully penetrate the cell membrane of tumor cells into the nucleus, is the key to the use of polymer nano drug system to implement cancer treatment. However, due to the biological barrier function of the cell membrane, many high molecular substances are difficult to enter the cell, thereby greatly limiting the application of the polymer as a drug carrier in clinical treatment. At present, the "cell penetrating peptide" which effectively mediates the efficient entry of the vector into the cell, although the effective penetration of the cell membrane can be achieved, but due to its structural fixation, further functional modification is difficult.
In order to solve this problem, the research team of the School of Chemistry and Chemical Engineering of Hefei University of Technology has realized the rapid and efficient penetration of nano-carriers on cell membranes by simulating the function of cell penetrating peptides by synthetic polymer materials.
The results of cell level experiments confirmed that this new nanocarrier can smoothly cross the membrane within 20 minutes, and the penetration speed is nearly ten times higher than that of the conventional random polymer chain.
At the same time, the team also wrapped dye molecules and anticancer drugs inside the nanocarriers, and designed and prepared a series of multifunctional nanocarriers with the function of “combination and treatment integration†that can simultaneously load drugs and contrast agents.
"The widely used fluorescence methods cannot accurately reflect the location, extent and cell reproduction of tumors, and the determination of tumor development is not accurate enough. With this new system carrying contrast agent, the tumor site can be accurately observed by photoacoustic imaging, and even Tumor capillaries are expanded to more accurately determine tumor growth and provide early warning," said Associate Professor Yin Jun, team leader.
On this basis, the study realized the high-precision imaging diagnosis, and realized the controlled release of the drug program triggered by the environment inside the cancer cell, which made early warning and intervention of cancer possible.
(Hefei University of Technology develops nano drug carrier cancer early warning will become possible. Image source: Baidu image)
According to reports, to ensure that drug molecules can successfully penetrate the cell membrane of tumor cells into the nucleus, is the key to the use of polymer nano drug system to implement cancer treatment. However, due to the biological barrier function of the cell membrane, many high molecular substances are difficult to enter the cell, thereby greatly limiting the application of the polymer as a drug carrier in clinical treatment. At present, the "cell penetrating peptide" which effectively mediates the efficient entry of the vector into the cell, although the effective penetration of the cell membrane can be achieved, but due to its structural fixation, further functional modification is difficult.
In order to solve this problem, the research team of the School of Chemistry and Chemical Engineering of Hefei University of Technology has realized the rapid and efficient penetration of nano-carriers on cell membranes by simulating the function of cell penetrating peptides by synthetic polymer materials.
The results of cell level experiments confirmed that this new nanocarrier can smoothly cross the membrane within 20 minutes, and the penetration speed is nearly ten times higher than that of the conventional random polymer chain.
At the same time, the team also wrapped dye molecules and anticancer drugs inside the nanocarriers, and designed and prepared a series of multifunctional nanocarriers with the function of “combination and treatment integration†that can simultaneously load drugs and contrast agents.
"The widely used fluorescence methods cannot accurately reflect the location, extent and cell reproduction of tumors, and the determination of tumor development is not accurate enough. With this new system carrying contrast agent, the tumor site can be accurately observed by photoacoustic imaging, and even Tumor capillaries are expanded to more accurately determine tumor growth and provide early warning," said Associate Professor Yin Jun, team leader.
On this basis, the study realized the high-precision imaging diagnosis, and realized the controlled release of the drug program triggered by the environment inside the cancer cell, which made early warning and intervention of cancer possible.
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