For Professor Mazhar Adli of the University of Virginia, these little dots flying on the computer screen represent the realization of his dreams. The real-time movement of these fluorescent dots indicates a way that has never been seen before, and we hope to have a new understanding of the human genome, cancer and genetic diseases.
Professor Mazhar Adli's team developed a method for tracking genes in living cells in real time, allowing specific gene fragments to shine. In this way, people can observe the position and movement path of the gene in the cell from a three-dimensional perspective, just like watching the stars in space with an astronomical telescope. This important breakthrough was published in the recent Nature, a subsidiary of Nature Communications.
â–² Real-time observation of a fragment of HeLa cell chromosome 17 by new technology (Source: Nature Communications)
Localization in cells and relative position to other genes can have an important effect on the effects of a gene. Therefore, targeting the three-dimensional localization of specific genes in cells will hopefully help scientists to deepen our understanding of how genes work and interact, and how we affect our health.
â–² article communication author Professor Mazhar Adli (left) and Professor Ahmet Yildiz (right) (Source: University of Virginia and University of California, Berkeley official website)
“I have been doing this dream for a long time,†Professor Mazhar Adli said. “We can observe real-time observations in almost any area of ​​the genome in living cells, and it works well. With traditional standard methods, you are basically never. You will get this data because you have to kill the cells to do this imaging, but we can now do real-time imaging in live cells."
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