CAR-T cells can effectively treat solid tumors

Cell therapy is not effective for the treatment of solid tumors, in part because cancer-specific T cells are difficult to transport into tumor tissue. Today, a technology developed by researchers at the Fred Hutchinson Cancer Research Center can help. Researchers use a synthetic "skeleton" to mix cancer-specific T cells with some nutrients to achieve the effect of killing tumor cells.

The findings were published in the most recent issue of the Journal of Clinical Investigation. The results showed that this T cell-loaded backbone can effectively reduce the tumor size of mouse pancreatic cancer and melanoma, and the therapeutic effect is higher than that of T cells alone.

T cells are more demanding on the living environment. If there is no suitable nutrient and the method of discharging waste, it will die within a few days. In addition, tumor tissue releases some self-defense chemicals that prevent the normal functioning of T cells. Therefore, it is not only possible to enter the tumor tissue to be expected to function.

CAR-T细胞可有效治疗实体肿瘤

Therefore, Stephan et al. designed a warm "home " that hopes to solve these problems.

This viscous, spongy biopolymer has a number of tiny apertures that can be made in different sizes and shapes. Stephan collaborated with researchers at the Massachusetts Institute of Technology to introduce CAR-T cells into this framework and inject proteins that maintain T cell activity.

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