Recently, two studies conducted by researchers from the University of Pennsylvania School of Medicine have shown that by injecting antibodies, it can lower the fat content in the blood and further alleviate the coronary arteriosclerosis caused by fat, cholesterol and other substances deposited on the arterial wall. symptom.
The new technology targets a class of proteins called ANGPTL3, which regulates the activity of enzymes that scavenge triglycerides in the blood. Some studies in recent years have shown that genetic mutations in ANGPTL3 can lower levels of triglycerides, LDL cholesterol, and HDL cholesterol in the blood.
According to a recent article published in the New England Journal of Medicine, researchers have studied the ANGPTL3 protein in mice and humans and found that inhibition of ANGPTL3 activity by injection of antibodies (evinacumab) can reduce 76% of patients. The level of triglycerides and the level of 23% cholesterol, the mouse model also proved that the treatment can alleviate the symptoms of arteriosclerosis.
The researchers also performed genetic tests on 188,000 participants, and the results showed that individuals with ANPGTL3 mutations had a 40% lower risk of coronary heart disease compared with the control group.
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