Release date: 2015-05-29
According to a large study published in the American Journal of Neurology's medical journal Neurology on May 20, 2015, people with depression may be more susceptible to Parkinson's disease.
“We have observed the link between depression and Parkinson's disease for more than two decades, so depression may be an early symptom of Parkinson's disease or a risk factor for the disease.†Dr. Peter Nordstrm said the study Published in the journal of Umeå University in Sweden.
The researchers also studied the association between siblings and sisters. No one found that one child had depression and the other had a connection with Parkinson's disease. "This discovery provides us with more evidence that the two diseases are related," Nordstrm said. "If the two diseases are independent of each other, but they are caused by the same genetic or environmental factors in the early days, then we will see that these two diseases will occur between siblings, but in fact this has not happened."
In this study at the end of 2005, researchers began researching all Swedish citizens aged 50 and over. They identified 140,688 people who were diagnosed with depression between 1987 and 2012 as experimental groups. These individuals were paired with three control groups. The gender and birth year of the participants in the control group were the same as those in the experimental group and were not diagnosed as depression. A total of 421,718 participants were used as the control group.
The study was followed by a 26-year follow-up survey. During this period, 1485 patients with depression were associated with Parkinson's disease, accounting for 1.1%, while 1,775 people did not suffer from depression and suffered from Parkinson's disease, accounting for about 0.4%.
Patients who were diagnosed with Parkinson's disease on average 4.5 years after the start of the study. The likelihood of developing Parkinson's disease gradually decreases over time. Compared with people without depression, depression patients were 3.2 times more likely to develop Parkinson's disease within one year after the start of the study. In the 15 to 25 years after the start of the study, people with depression have a 50% chance of developing Parkinson's disease.
More severely depressed patients are also more susceptible to Parkinson's disease. Compared with patients who have been hospitalized for only one time due to depression, patients who have been hospitalized for more than five times due to depression have a 40% chance of developing Parkinson's disease. Patients hospitalized for depression have a 3.5-fold chance of developing Parkinson's disease compared with those treated with outpatients for depression.
When the researchers adjusted other conditions associated with depression, the association between depression and Parkinson's disease did not change, such as traumatic brain injury, stroke, alcohol, and drug abuse.
Source: Bio Valley
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