"Four in one" flu vaccine may enhance protection against viruses

Recently, researchers from the Las Vegas Medical Center found that a special vaccine from four major flu virus "ancestral genes" seems to provide more protection against the flu virus. Role, related research results published in the international journal Scientific Reports. The researchers said that mice protected by unconventional vaccines were able to survive exposure to nine different influenza viruses (both of which were lethal doses), and that mice receiving high-dose vaccines did not even get sick. .
In contrast, mice receiving traditional flu shots or nasal sprays can become sick or even die when exposed to the same virus. These lethal pathogens evade the immune response induced by traditional viruses. Although it is still too early to say that this method can be successfully applied in human organisms, it seems that this provides a research basis for later researchers to develop a universal influenza vaccine.
Researcher Weaver said the study reports whether we can use a combination of multiple genes to develop generic flu vaccines that share some traits at ancestral levels. The ultimate researcher's goal is to develop a flu vaccine that provides lifelong protection with only one injection. According to US CDC data, approximately 40 million Americans were infected with the flu virus during the 2015-2016 flu season, and 970,000 individuals were admitted to hospital for treatment. Because influenza viruses can mutate rapidly, and humans, animals, and birds carrying viruses usually do not show any symptoms, it is difficult for researchers to develop a flu vaccine that provides long-term protection. The conventional flu vaccine platform. The virulence weakened or dead flu virus will be used to stimulate the body to produce immunity against influenza virus hemagglutinin.
Some experts believe that it is difficult to get a generic flu vaccine until 2020 or 2025. The road to finding a generic flu vaccine is difficult. Some scientists try to use a variety of methods to better match vaccines to multiple viruses, while others Research strategies include the development of vaccines that target viral outer membrane proteins and more. These methods have shown good prospects. However, in this study, researchers Weaver and colleagues first reported the use of a variety of centralized hemagglutinin genes to provide maximum cross-immunity protection.
In this study, the new methods used by researchers can be applied to humans and provide a fully long-lasting anti-influenza protection mechanism for the human body. Instead of using previously virulence-degraded or deadly flu viruses, the researchers used a replication-defective adenovirus (which triggers common flu) that can be altered to carry the sequences of the H1, H2, H3, and H5 influenza virus consensus genes. At the same time, the vaccine developed does not cause individuals to develop flu symptoms, and can safely transport influenza vaccine genes.
Finally, the researchers said that this concentrated antigen can fight the immunity of the body against the flu virus, especially because it has a certain concentration and can represent all flu strains equally, so it can also provide protection against the body. The special immunity of the evolutionary flu virus.

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