Release date: 2018-04-11
Immune cell aging can exacerbate the development of macular degeneration. (Source: Danyel Cavazos/ Michael Worful)
The latest study, published in the June issue of JCI Insight, was completed by scientists from the University of Washington School of Medicine. They have recently discovered that aging of macrophages increases eye inflammation and abnormal blood vessel growth, thereby increasing the risk of age-related macular degeneration.
"Therapeutic agents for macular degeneration have little or no effect on some patients," said Rajendra S. Apte, a well-known author of the article, author of the ophthalmology and visual sciences. "Now, by analyzing the role of the immune system in the eye." It is expected to develop new treatment strategies to help patients who are not responding to existing drugs."
Doi:10.1172/jci.insight.120157
Latest discovery
Using a mouse model, Rajendra S. Apte and the team found that aging macrophages carry more microRNAs responsible for regulating gene expression, particularly microRNA-150 (abnormal increase in levels). They further confirmed that microRNA-150 drives aging macrophages to trigger eye inflammation and abnormal angiogenesis.
In addition, the team also used high blood levels of microRNA-150 as a sample of blood from patients with macular degeneration. "We believe that microRNA-150 is a potential therapeutic target, or at least a biomarker, to assess the risk of this eye disease and loss of vision," said Dr. Jonathan B. Lin.
Significance
"The treatment of macular degeneration seems to be more about disease, not its cause. Now, our focus is on macrophages (regulating inflammation, angiogenesis), a shift that helps prevent the progression of the disease, so that More patients benefit,†explains Dr. Jonathan B. Lin.
If the level of microRNA in macrophages can be reduced in some way, or by altering one or more molecular channels regulated by microRNAs, this would hopefully reduce the level of inflammation and prevent the formation of abnormal blood vessels in the eye. Researchers believe that this strategy can be extended to other diseases related to aging.
Rajendra S. Apte believes that this study reminds us that slowing the aging of cells can control the loss of vision.
Reference materials:
Macular degeneration linked to aging immune cells
Source: Bio-Exploration
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