The pharmacological effects of corn silk

Pharmacological effects

1. Diuretic effect

Maize water decoction 5g/kg, 10g/kg gavage, the bear significantly increased the urine volume of the first 1 and 2 hours after administration of awake rabbits, and the high-dose group had a strong effect, weaker but more lasting than furosemide. Water extract 1, 5mg/kg intravenous injection, 4min after the first diuretic effect of rabbits, 13 ~ 15min after the emergence of a strong second diuretic effect. Neutralization with sodium hydroxide, followed by dialysis of the bladder membrane, the diuretic effect unchanged, indicating that the diuretic component is not containing inorganic salts.

The product has a diuretic effect by oral or subcutaneous injection. After administration, the concentration of chloride in the blood increases first, and then the amount of urine and chloride in the urine increase. The diuretic mechanism of action is mainly extrarenal and has a synergistic effect with caffeine. Corn must be made of a l0g decoction orally. Mild diuretic effect on normal people, but weaker than swine fever and caffeine. There are also reports of double-demonstration studies of clinical deaths.

There was no significant difference in urine volume and urinary sodium excretion between the 12h and 24h of the product and the control group.

2. Antihypertensive effect

Maize aqueous extract, ethanol aqueous extract, alcohol extract and decoction, intravenous anesthetic dogs, cats and rabbits have antihypertensive effect. With its decoction to the anesthetized dogs intravenous (0.05 ~ 0.2g/kg) or irrigation (2g/kg), so that blood pressure were reduced by 30% -73% and 53%, which lasted 2 ~ 5h and 5 ~ 10h recovery. Maize to be boiling water dialysate (1.37 ~ 22mg/kg) to the normal anesthesia dogs intravenously, there is a dose-dependent antihypertensive effect, 15min onset, maintain 80min, accompanied by significant reduction in heart rate. However, it has also been reported that the same dose of the awakening dog fed for 3 weeks, no antihypertensive effect; hypertensive rats intraperitoneal injection of corn must have antihypertensive effect, but no effect on normal rats. The decompression mechanism is mainly central, and it is also thought to be mainly the result of dilating the peripheral blood vessels. Corn must be able to counter the adrenaline boost effect. Small doses of corn must have no effect on the heart. At higher doses, the heart rate is slower and less intense.

3. The role of gallbladder

Maize must have a significant increase in bile secretion and promote biliary excretion, which can reduce the organic matter and slag content in bile, and reduce the viscosity, specific gravity, and bilirubin content. The reflex contraction of gallbladder and the increase of bile selection occurred 15-30 minutes after oral administration of corn stimuli. This effect is slower than magnesium salts, but it is more persistent and does not involve increased bowel movements and loose stools.

4. Hypoglycemic effect

The fermented corn silk preparation had obvious hypoglycemic effect on rabbits; water decoction 7, 5g/kg, 15g/kg, 30g/kg gavage, continuous for 7d, had significant effect on alloxan-induced diabetes in mice. Therapeutic effects also have significant hypoglycemic effects on glucose and epinephrine-induced hyperglycemia in mice. However, there is a clear dose-effect relationship, but no significant effect on blood pressure in normal mice. Tip corn may be the role of dual muscle hypoglycemic drugs.

5. Other effects

Corn water release agent 15g/kg, 30g/kg, gavage 7d, can significantly reduce serum cholesterol levels in hypercholesterolemic mice. Corn must contain vitamin K, which has a curative effect on coagulation dysfunction caused by vitamin K deficiency.

6. toxicity

Maize preparations were almost non-toxic, water decoction was administered to the stomach, and the maximum tolerated dose in mice was >171 g/kg. The water-injection methanol-insoluble fraction (diuretic component) was given as a lethal dose of 250 mg/kg intravenously for rabbits and 1.5 mg/kg for the optimal diuretic dose and 6 mg/kg for oral use. The above diuretic doses were associated with cardiac, respiratory, and peripheral blood vessels. And intestinal muscle has little effect.

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